Optimal Treatment for Subarachnoid Neurocysticercosis: Closer, but Not There yet

Closer but not there yet: models in child injury research.

Neurocysticercosis: Neglected but Not Forgotten

1 Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Departments of Neurology and Global Health, University of Washington, Seattle, Washington, United States of America,...

Die—but not just yet

eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...

Vpu and BST2: Still Not There Yet?

Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV type 1 (HIV-1) replication and are widely accepted as "restriction factors." APOBEC3G was identified as a restriction factor that diminishes HIV-1 replication by inducing G-to-A hypermutation in the viral genome, while BST2 has been identified as another restriction factor that impairs the release...

Preprescription genotyping: not yet ready for prime time, but getting there.

There are few, if any, situations in medicine in which a clinician can predict with certainty an individual’s response to drug therapy. A host of factors can modulate this response: concomitant disease or drug therapy, sex, age, ethnicity, or dysfunction of excretory organs, to name but a few. Even when we correct for changes anticipated by such conditions, however, drug responses remain highly...